In this recently published study, investigators in the United States conducted a study "To determine the relationship between doses of gemcitabine and absolute neutrophil count and thrombocytopenia in patients with severe hepatic dysfunction (total bilirubin >= 4.5 mg/dL), and the relationship between doses of gemcitabine in patients with severe hepatic dysfunction and nonhematologic toxicity. SUMMARY: A retrospective chart review was conducted for patients receiving gemcitabine at the Medical University of South Carolina from October 2006 through October 2008."
"Seven patients were identified who had an elevated total bilirubin level (>= 4.5 mg/dL) at the time they …

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